PDF Files

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Stapleton, G., Steel, M., Richardson, M., Mason, J.O., Rose, K.A., Morris, R.G.M. and Lathe, R. (1995). A novel cytochrome P450 expressed primarily in brain. J. Biol. Chem. 270, 29739-29745. (pdf)

Lathe, R. (1996). Mice, gene targeting and behaviour; more than just genetic background.  Trends Neurosci. 19, 183-186. (pdf)

Rose, K.A., Stapleton, G., Dott, K., Kieny, M.P., Best, R., Schwarz, M., Russell, D.W., Björkhem, Seckl, J. and Lathe, R. (1997). Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc. Natl. Acad. Sci. USA 94, 4925-4930. (pdf)

Dobie K, Mehtali M, McClenaghan M, Lathe R. (1997) Variegated gene expression in mice. Trends Genet. 13, 127-130. (pdf)

Steel, M., Moss, J., Clark, K.A., Kearns, I.R., Davies, C., Morris, R.G.M., Skarnes, W.C. and Lathe, R. (1998). Gene-trapping to identify and analyze genes expressed in the mouse hippocampus.Hippocampus 8, 444-457. (pdf)

Davies, B.J., Pickard, B.S., Steel, M. and Morris, R.G.M. and Lathe, R. (1998) Serine proteases in rodent hippocampus. J. Biol. Chem. 273, 23004–23011. (pdf)

Setchell, K.D.R., Schwarz, M., Lund, E.G., Davis, D.L., Lathe, R., Sokol, R.J. and Russell, D.W. (1998). Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J. Clin. Invest. 102, 1690-1703. (pdf)

Pickard, B.S., Davies, B.J., Rose, K.A., Stapleton, G., Steel, M. and Lathe, R. (1999). Brain region-specific genes: the hippocampus. In Crusio, W.E. and Gerlai, R. (eds.) Handbook of Molecular Genetic Techniques for Brain and Behaviour Research, Elsevier, pp 212-224. (pdf)

Lathe, R. (2001) Hormones and the hippocampus. J. Endocrinol. 169, 205-231. (pdf)

Rose, K., Allan, A., Gauldie, S., Stapleton, G., Dobbie, L., Dott, K., Martin, C., Wang, L., Hedlund, E., Seckl, J.R., Gustafsson, J.A. and Lathe, R. (2001). Neurosteroid Hydroxylase CYP7B: Vivid Reporter Activity in Dentate Gyrus of Gene-Targeted Mice and Abolition of a Widespread Pathway of Steroid and Oxysterol Hydroxylation. J. Biol. Chem. 276, 23937-23944. (pdf)

Davies, B., Kearns, I., Ure, J., Davies, C. and Lathe, R. (2001). Loss of hippocampal serine protease BSP1/Neuropsin predisposes to global seizure activity. J. Neuroscience 21, 6993-7000. (pdf)

Lathe, R., and Seckl, J.R. (2002). Neurosteroids and brain sterols. In: Mason, J.I. (ed.) Genetics of Steroid Biosynthesis and Function. Modern Genetics, volume 6, Harwood Academic, pp 405-472. (pdf)

Lathe, R. (2002). Steroid and sterol 7-hydroxylation: Ancient pathways. Steroids 67, 967-977. (pdf)

Weihua Z, Lathe R, Warner M, Gustafsson JA. (2002) An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc. Natl. Acad. Sci. USA. 99, 13589-13594. (pdf)

Yau, J.L.W., Rasmuson, S., Andrew, R., Graham, M., Noble, J., Olsson, T., Fuchs, E., Lathe, R. and Seckl, J.R. (2003). DHEA 7-hydroxylase CYP7B: Enrichment in primate hippocampus and functional depletion in Alzheimer’s disease. Neuroscience 121, 307-314. (pdf)

Lathe, R. (2004) Fast tidal cycling and the origin of life. Icarus 168, 18-22. (pdf)

Lathe, R (2004) The individuality of mice. Genes Brain Behav. 3, 317-327. (pdf)

Omoto, Y., Lathe, R., Warner, M. and Gustafsson, J.A. (2005) Early onset of puberty and early ovarian failure in CYP7B1 knockout mice. Proc. Natl. Acad. Sci. USA 102, 2814-2819. (pdf)

Lathe, R. (2005) Tidal chain reaction and the origin of replicating biopolymers. Intl. J. Astrobiol. 4, 19-31. (pdf)

Lathe, R (2006) Early tides – response to Varga et al. Icarus 80, 277-280.(pdf)

Nataf, R., Skorupka, C., Amet, L., Springbett, A. and Lathe, R. (2006) Porphyrinuria in autistic disorder; implications for environmental toxicity. Toxicol. App. Pharmacol. 214, 99-108. (pdf)

Lathe, R. (2006) Autism and the link between brain and body. ASA Autism Advocate Online, Special Issue, December. (pdf)

Nataf R, Skorupka C, Lam A, Springbett A, Lathe R. (2008) Porphyrinuria in childhood autistic disorder is not associated with urinary creatinine deficiency. Pediatr Int. 2008 50, 528-532. (pdf)

Lathe, R. (2008) Environmental factors and limbic vulnerability in childhood autism. Am. J. Biochem. Biotech. 4, 183-197. (pdf)

Lathe, R (2009). Microwave electromagnetic rediation and autism. EJAP 5, 11-30. pdf